含有雌激素的口服避孕药与甲状腺功能低下症之间的关联
Lama Alkahlout1, Shahd Hamran1, Nour Darwish1
1College of Medicine, QU Health, Qatar University, Doha, Qatar.
International journal of endocrinology
|March 26, 2025
概括
含有雌激素的口服避孕药 (OCP) 可能会增加女性甲状腺功能低下的风险. 较高的性激素结合环球蛋白 (SHBG) 水平,这是OCP使用的标志物,与甲状腺功能低下的几率增加相关,特别是在更高的百分位.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
背景情况:
- 甲状腺功能低下症是一种常见的内分泌疾病,不成比例地影响女性.
- 含有雌激素的口服避孕药 (OCPs) 对甲状腺功能的影响尚不清楚.
- 本研究研究了卡塔尔妇女使用OCP和甲状腺功能低下症之间的联系.
研究的目的:
- 调查卡塔尔女性中含有雌激素的OCP使用与甲状腺功能低下之间的关联.
- 评估性激素结合型全球蛋白 (SHBG) 作为OCP使用的替代品.
- 为了确定与SHBG水平相关的甲状腺功能低下的几率,调整混因素.
主要方法:
- 在卡塔尔生物银行的1001名女性参与者中进行了横截面研究,他们有OCP史.
- 甲状腺功能通过TSH和FT4水平进行评估.
- 多变量逻辑回归用于分析SHBG水平和甲状腺功能低下的几率,控制年龄,种族和糖尿病.
主要成果:
- 3.4%的参与者患有甲状腺功能低下症.
- 较高的SHBG水平显示甲状腺功能低下的几率增加,特别是在第95个 (OR 1.46) 和第99个 (OR 10.07) 百分点.
- 与卡塔尔人相比,非卡塔尔阿拉伯人患甲状腺功能低下的几率更高 (OR 8.06).
结论:
- SHBG水平作为含有雌激素的OCP使用的指标.
- 升高的SHBG水平与OCP使用者的甲状腺功能低下风险增加有关.
- 在OCP使用者中甲状腺功能低下风险的种族差异需要进一步调查潜在机制.
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