后COVID状况和长期COVID-19对肝脏衰竭和肝硬化生存的影响:一种倾向匹配的观察研究
Prerna Sharma1, Madhumita Premkumar1, Rashmi Ranjan Guru2
1Department of Hepatology Postgraduate Institute of Medical Education and Research Chandigarh India.
概括
在肝硬化患者中,COVID-19显著增加了长期死亡风险,其中三分之一的人患有COVID后疾病 (PCC). 梅尔德纳分数,年龄和高血压预测了康复后的死亡率.
科学领域:
- 肝病学和传染病的研究
- 关键护理医学 关键护理医学
- 后COVID条件研究研究研究
背景情况:
- 肝硬化患者在COVID-19感染后面临更高的去补偿和死亡风险.
- 后COVID状态 (PCC) 可以表现为持续数月的多系统参与.
研究的目的:
- 评估COVID-19住院肝硬化患者的脱补偿事件和死亡率.
- 为了将结果与非COVID-19败血症肝硬化患者的倾向匹配队列进行比较.
- 确定这一群体中COVID后病情 (PCC) 和死亡率的发生率和预测因素.
主要方法:
- 住院COVID-19肝硬化患者的回顾性评估 (2021年1月至2023年1月).
- 与患有非COVID-19败血症的肝硬化患者的倾向匹配队列进行比较.
- 对脱补偿事件,死亡率和PCC的发展进行一年的随访.
主要成果:
- 肝硬化+COVID-19的住院死亡率为28.6%,类似于非COVID败血症 (27.1%).
- 晚期死亡率在肝硬化+COVID-19患者中明显高于非COVID败血症患者 (56.1%与35.3%,p=0.026).
- 33.3%的COVID-19幸存者患有PCC,症状包括呼吸障碍,认知障碍和焦虑. 基线MELDNa和年龄预测PCC发展. 梅尔德纳,年龄和高血压预测了恢复后的死亡率.
结论:
- COVID-19与肝硬化患者的长期死亡率增加有关,超过了急性感染阶段.
- 后COVID状况 (PCC) 影响了COVID-19从COVID-19中恢复过来的肝硬化患者的很大一部分 (33.3%).
- 确定PCC和死亡率的预测因素对于管理COVID-19后肝硬化患者至关重要.
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