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在T2N1M0和T3N0M0分叶乳腺癌患者之间死亡风险因素的差异:一项比较研究

Longjie Xia¹, Chunxin Qin², Wei Chen³

¹College of Life Science and Technology, Guangxi University, Nanning, China.

Frontiers in pharmacology

|March 26, 2025

概括

在T2N1M0和T3N0M0叶状乳腺癌之间,死亡风险因素有所不同. 放射治疗可能会增加T3N0M0患者的肺相关死亡风险,影响治疗选择.

科学领域:

在瘤学瘤学.
医学统计医学统计

背景情况:

叶状乳腺癌 (LBC) 阶段 (T2N1M0与T3N0M0) 影响预后.
了解不同的死亡风险因素对于个性化治疗至关重要.

研究的目的:

为了比较T2N1M0和T3N0M0叶状乳腺癌之间的死亡风险因素.
确定与非叶状乳腺癌死亡率相关的因素.

主要方法:

从SEER数据库 (2008-2018) 中分析了2,693名T2N1M0和1,384名T3N0M0LBC患者.
卡普兰-梅尔曲线和Log-rank测试用于生存比较.
考克斯比例危险回归用于死亡风险因素的识别.

主要成果:

在T2N1M0和T3N0M0组之间的整体存活时间有显著差异 (p=0.0011).
T3N0M0组的肺相关疾病死亡率较高 (p=0.0023).
年龄,手术,放射治疗和化疗是独立的死亡因素;在T3N0M0 (HR=2.076) 中,放射治疗增加了与肺相关的死亡风险.

结论:

与T2N1M0.0患者相比,LBC患者面临更高的肺相关死亡风险.
放射治疗可能会增加T3N0M0患者的肺相关死亡风险.
结果有助于优化治疗策略和患者-医生决策.

关键词:

T2N1M0 在线观看 T3N0M0 在线观看额叶性乳腺癌额叶性乳腺癌肺相关疾病死亡率,死亡率.辐射疗法辐射疗法

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