复杂的,低强度的,个性化的自然发展行为干预在自闭症谱系障碍的幼儿和学龄前儿童:多中心,观察者盲,平行组随机对照A-FFIP试验
Christine M Freitag1, Marietta Kirchner2, Lukas D Sauer2
1Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Autism Research and Intervention Centre of Excellence, University Hospital Frankfurt, Goethe-University, Frankfurt am Main, Germany.
概括
与通常的护理相比,法兰克福自闭症谱系障碍早期干预计划 (A-FFIP) 并没有显著改善ASD幼儿的社交沟通. 然而,A-FFIP在减少重复行为和增强执行功能方面显示出潜在的好处.
科学领域:
- 发展心理学 发展心理学
- 临床心理学 临床心理学
- 神经发育障碍 神经发育障碍
背景情况:
- 自然主义发展行为干预 (NDBI) 显示出改善自闭症谱系障碍 (ASD) 的幼儿和学龄前儿童的社交沟通的希望.
- 法兰克福ASD早期干预计划 (A-FFIP) 是一种低强度,复杂的NDBI,旨在针对ASD儿童的核心发育领域.
研究的目的:
- 评估A-FFIP干预措施在一年内改善ASD儿童社交沟通的有效性.
- 为了将A-FFIP与常规的早期干预 (EIAU) 在III期随机对照试验中进行比较.
主要方法:
- 一项前性,随机,受控,并行组研究,涉及134名被诊断患有自闭症的24-66个月龄的儿童.
- 参与者被分配到手动的A-FFIP干预或EIAU.
- 主要结局是自闭症核心症状的变化,通过从基线到12个月的简要观察通信变化 (BOSCC) 总得分来衡量,从基线到12个月.
主要成果:
- 该研究发现,A-FFIP和EIAU组之间的主要结果 (社会沟通) 没有显著差异.
- SARS-CoV-2 流行病对试验程序产生了重大影响,并导致两组的改善减少.
- 二次分析表明,A-FFIP组的家长评价的重复行为和家长和教师评价的执行功能有所改善.
结论:
- 在一年后,A-FFIP计划没有在改善ASD儿童的社交沟通,认知或行为结果方面表现出优于EIAU的优势.
- 在这种人群中,A-FFIP可能会在解决重复行为和执行功能方面提供好处.
- 需要进一步的研究来探索A-FFIP的特定组件,这些组件可能有助于这些观察到的次要好处.
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