比格尔作为素和酸联合递送系统:可控释放和增强生物可用性
Xinyao Wang1,2, Hui Tang2, Mengjuan Chen3
1College of Food Science and Technology, Hunan Agricultural University, Changsha, China.
糖醇单酸盐 (GML) 和低酸 (LA) 的大豆增强了素 (CAP) 和酸 (GA) 的稳定性和生物可用性. 这种新的联合交付系统可以提高功能性食品中这些天然生物活性物质的有效性.
科学领域:
- 食品科学与技术 食品科学与技术
- 营养药和生物活性药物
- 药物输送系统 药物输送系统
背景情况:
- 像素 (CAP) 和酸 (GA) 这样的天然生物活性物因其健康益处而受到越来越多的关注.
- 低生物可用性阻碍了CAP和GA在功能性食品中的应用.
- 之前已经开发了一种使用甘单一酸盐 (GML) 和低酸甘 (LA) 的比格尔系统.
研究的目的:
- 评估GML-LA大作为CAP和GA的联合交付系统的有效性.
- 研究大对CAP和GA的稳定性,消化释放和生物可用性的影响.
主要方法:
- 在GML-LA大片中,CAP和GA的共同封装.
- 在12天内在4°C下对封装的CAP和GA进行稳定性评估.
- 在体外消化模拟以分析释放动力学.
- 卡科-2细胞单层模型,以确定吸收和生物可用性.
主要成果:
- 与自由形式相比,Bigel显著提高了CAP和GA的稳定性.
- 在4°C下12天后,CAP的保留率为71.13%,GA的保留率为83.34%.
- 试验室消化证明了从大头中控制和持续释放CAP和GA的情况.
- >40%的CAP和>30%的GA在模拟肠道消化后仍未释放.
- 在大牛系统中,CAP和GA的生物可用性分别增加了1.35倍和1.77倍.
结论:
- GML-LA大果有效地提高了联合封装的CAP和GA的稳定性和生物可用性.
- 比格尔系统为开发具有提高生物活性功效的新功能食品提供了一个有希望的方法.
- 这项研究为利用自然生物活性物与增强的输送系统提供了新的视角.
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