父母精神疾病和子女患大抑郁症的特定年龄风险:芬兰全国基于登记册的研究
Subina Upadhyaya1,2, Dan Sucksdorff1,3, Miina Koskela1,4
1Department of Child Psychiatry, Research Centre for Child Psychiatry, University of Turku, Turku, Finland.
Psychological medicine
|March 26, 2025
概括
父母精神疾病显著增加后代患重度抑郁症 (MD) 的风险. 当父母都有精神病诊断时,这种风险是最高的,特别是儿童早期的MD.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 关于父母全方位精神病理学与后代严重抑郁症 (MD) 之间的联系的研究有限.
- 之前的研究没有根据后代MD的发病年龄或考虑后代出生前父母的诊断来调查这种关联.
研究的目的:
- 检查家长心理病理与后代严重抑郁症 (MD) 之间的关联.
- 调查MD在后代的发病年龄是否会改变这种关联.
- 探索父母在后代出生前做出的精神病诊断对MD风险的影响.
主要方法:
- 一项嵌套的病例控制研究利用了芬兰的国家登记册.
- 包括37,677个MD病例和145,068个对照病例.
- 条件后勤回归模型分析了相关性,并对混因素进行了调整.
主要成果:
- 父母诊断的精神分裂症,精神分裂情绪障碍,抑郁症和行为障碍与后代MD风险增加有关.
- 母亲的精神病理显示出比父亲 (aOR 1.95) 的风险更高 (aOR 2.66).
- 当父母双方都有诊断时,后代患MD的风险大幅增加 (aOR4.50),特别是在早期发病的MD (5-12岁).
- 这种联系在男孩中比女孩更强烈,特别是在青少年和年轻成人后代中.
结论:
- 父母的精神疾病与后代的MD有关,这表明共同的遗传和环境影响.
- 这些发现强调了考虑父母心理健康史在了解MD发展方面的重要性.
- 在后代中早期发病的MD特别与两个父母患有精神病诊断有关.
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