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Updated: May 20, 2025

Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators
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Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators

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酵素氨基化用于对循环素的立体控制功能化

Juzhang Yan1,2, Jinping Bao1,2, Chengsen Cui1,3

  • 1State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.

Angewandte Chemie (International ed. in English)
|March 26, 2025
PubMed
概括

这项研究引入了一种使用工程化胺基还原酶 (IREDs) 来立体选择性合成奇拉环胺的酶性还原性氨基化方法. 这种新的方法克服了当前化学合成制造复杂循环胺的局限性.

关键词:
轴向性拉性 轴向性拉性生物催化剂是一种生物催化剂.希拉尔的环基胺.在Cis/Trans的立体化学中.伊胺还原酶可以减少.

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