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Updated: May 20, 2025

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1

Published on: August 24, 2015

简单疹病毒1封面糖蛋白C屏蔽糖蛋白D以保护病毒从阻断入口的抗体

McKenna A Hull¹, Suzanne M Pritchard¹, Anthony V Nicola¹

¹Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA.

Journal of virology

|March 26, 2025

概括

简单疹病毒1糖蛋白C (gC) 保护糖蛋白D (gD) 免受中和抗体的影响. 这种屏蔽机制有助于病毒逃避免疫检测,并促进感染.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
结构生物学结构生物学

背景情况:

简单疹病毒1 (HSV-1) 的进入依赖于糖蛋白D (gD) 与宿主细胞受体的相互作用.
针对gD的中和抗体对于防止病毒进入至关重要.
HSV采用免疫逃避策略,需要对其机制进行研究.

研究的目的:

研究HSV-1糖蛋白C (gC) 在保护gD免受抗体中和方面的作用.
为了确定CG是否屏蔽了gD的受体结合或融合介导域.

主要方法:

关于中和敏感性的HSV-1野生类型和Gh-null (ΔgC) 病毒的比较.
对野生类型的gD抗体对野生类型的gD抗体反应的评估,与Gc-null病毒包裹相比.
对两种病毒类型的可溶性nectin-1结合和进入抑制的分析.

主要成果:

与野生型病毒相比,HSV-1 ΔgC对抗gD抗体中和的敏感性增加.
在Cg-null病毒中的gD对抗gD抗体的反应性增强.
虽然可溶性 nektin-1 的结合是相似的,但HSV-1 ΔgC 进入对可溶性 nektin-1 的抑制更为敏感.

结论:

HSV-1 gC在物理上保护gD免受中和抗体的影响,包括那些向受体结合和gH/gL相互作用部位的抗体.
这种Cg的屏蔽是一种新的免疫逃避机制,促进HSV-1细胞的进入,并促进持久性感染.

关键词:

抗体是对抗体的重要组成部分.葡萄糖蛋白 C 是一种葡萄糖蛋白 C.葡萄糖蛋白D D 是一种葡萄糖蛋白.疹简单病毒病毒.中和化中和化中和化结合受体与受体的结合方式病毒葡萄糖蛋白是病毒的葡萄糖蛋白.

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