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在英格兰使用数据链接对乙型肝炎和C型肝炎死亡率的敏感性分析:达到世卫组织消除死亡率值

Annabel A Powell¹, Annastella Costella¹, Rachel Roche¹

¹Blood Safety, Hepatitis, Sexually Transmitted Infections (STIs) and HIV Division, UK Health Security Agency, London, UK.

Journal of viral hepatitis

|March 26, 2025

概括

英国的病毒性肝炎死亡率被低估,数据链接显示有37%的低报告率. 尽管如此,英国还是会见了世界卫生组织.

科学领域:

肝病学和公共卫生
流行病学和死亡率统计统计

背景情况:

英国的目标是到2030年消除病毒性肝炎,目标为每10万人口中≤6例死亡.
目前的死亡报告依赖于死亡登记,低估了多达60%的C型肝炎 (HCV) 相关肝病死亡.

研究的目的:

使用数据链接进行敏感性分析,以准确估计病毒性肝炎死亡率.
评估实现2030年病毒性肝炎消除目标的进展情况.
评估当前死亡数据中报告不足的程度.

主要方法:

来自死亡证明,乙型肝炎 (HBV) 和HCV诊断,以及末期肝病 (ESLD) /肝细胞癌 (HCC) 病例的相关数据.
分析涵盖了2000年至2023年期间.
敏感性分析以估计死亡率和报告不足.

主要成果:

相关数据确定了11,487人死于与HBV/HCV相关的ESLD/HCC,而仅仅是死亡登记的死亡人数为7,967,这表明总体报告不足的比例为37%.
2015年,高峰综合死亡率为每10万人1.3人,超过了世卫组织在所有评估年中的目标.
从2015年到2023年,HCV死亡率下降了 (1.12到0.88每10万),而HBV死亡率略有增加 (0.3到0.35每10万).

结论:

英格兰已经达到世卫组织的病毒性肝炎影响目标,主要是由于传统方法报告不足.
需要继续努力,以进一步降低病毒性肝炎的死亡率.
与HBV相关的死亡显示出明显的人口统计模式,与HCV相比,在伦敦以外的男性和非白人中,男性的比例更高.

关键词:

数据链接数据链接乙型肝炎 B 型肝炎型肝炎C型肝炎的发生死亡率死亡率

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