口服pH和炎症向输送系统,具有可生物降解的多层核心外纳米囊,用于治疗性结肠炎
Tian-Le Li1, Jie Zhou1, Jin-Long Gu1
1School of Basic Medical Sciences, Anhui Medical University, 81 Meishan Road, 230032 Hefei, Anhui, PR China. songmengmeng@ahmu.edu.cn.
新的多层纳米囊使生物药物能够通过口服输送,通过向炎症组织和减少炎症来改善性结肠炎 (UC) 的治疗. 这克服了注射和胃肠道退化的挑战.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物输送系统 药物输送系统
- 胃肠病学 胃肠病学
背景情况:
- 生物制剂的腹腔内注射会引起疼痛和不良服药,特别是在慢性疾病中.
- 由于恶劣的胃肠道环境,口服生物制剂具有挑战性.
- 性结肠炎 (UC) 需要有效和合规的治疗策略.
研究的目的:
- 开发一种新的多层核心外纳米囊配方,用于口服生物输送.
- 为了利用性结肠炎 (UC) 治疗中脑星细胞衍生神经变因子 (MANF).
- 为了提高治疗剂的向输送和胃肠道稳定性.
主要方法:
- 用MANF装载的氨酸改性纳米 (MBSH) 的制造.
- 进一步涂上酸盐和酸盐,以创建多层纳米囊 (MBSH@CA).
- 在DSS诱导的大肠炎模型中评估药物释放,生物分布,结肠积累和抗炎疗效.
主要成果:
- MBSH@CA纳米囊在模拟的胃和肠液中显示出最小的MANF释放 (<10%).
- 生物分布研究显示,24小时后,纳米囊在结肠中优先积累.
- 活体成像证实了炎症结肠中的增强积累,活体研究显示大肠炎引起的炎症显著减少.
结论:
- 开发的多层纳米 (MBSH@CA) 为口服向药物输送提供了一个有前途的平台.
- 这个系统有效地保护胃肠道中的生物物质,并准炎症的结肠组织.
- 通过减少炎症,MBSH@CA纳米囊显示出治疗性结肠炎的潜力.
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