巴西风湿关节炎中心血管疾病的发生频率:使用DATASUS数据库进行了为期10年的队列研究
Roberto Gamarski1, Fernando Ferreira de Castro1, Jose Antonio Sena do Nascimento1
1Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ - Brasil.
Arquivos brasileiros de cardiologia
|March 26, 2025
概括
心血管事件是常见的类风湿性关节炎 (RA) 患者治疗疾病修饰性抗风湿药物 (DMARDs). 高龄,并发症和合成DMARD使用与这些结果有关.
科学领域:
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 心血管疾病是类风湿性关节炎 (RA) 中的一个重要问题.
- 以前的研究集中在影响RA心血管结果的生物学因素上.
- 了解RA患者在巴西公共卫生系统中的心血管事件分布至关重要.
研究的目的:
- 在统一卫生系统 (SUS) 中确定巴西RA患者心血管事件的患病率.
- 在这个人群中确定与心血管结果相关的因素.
- 分析治疗模式,包括生物和合成修饰疾病的抗风湿药物 (DMARDs).
主要方法:
- 使用DATASUS数据库进行回顾性队列研究.
- 通过ICD-10代码和SUS程序识别了RA患者 (≥18岁).
- 根据DMARDs (生物与合成) 和治疗模式对患者进行分类;使用IFDM评估社会经济地位.
主要成果:
- 在4,321名服用DMARDs的RA患者中观察到198个心血管结局 (4.68%).
- 大多数是女性 (80.3%),平均年龄为54.2岁,主要来自巴西东南部.
- 晚年,心血管风险因素和合成DMARD使用与心血管不良事件有显著的相关性.
结论:
- 心血管结果代表了类风湿性关节炎患者的常见并发症.
- 治疗策略和患者的并发症显著影响心血管事件风险.
- 公共卫生倡议应解决RA患者的心血管风险,特别是那些服用合成DMARD的患者.
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