从名称到概念:解开牙科修复材料中的生物活性
Journal of the American Dental Association (1939)
|March 26, 2025
概括
牙科修复材料的生物活性主要得到实验室研究的支持,临床益处仍然不确定. 建议进行进一步的体外试验,以评估这些材料的治疗性离子释放和矿物质形成.
科学领域:
- 牙科材料科学 牙科材料科学
- 生物材料工程 生物材料工程
- 恢复性牙科 恢复性牙科
背景情况:
- 评估牙科修复材料的生物活性对于改善临床结果至关重要.
- 现有证据需要进行系统的评估,以了解其范围和类型.
- 这次审查遵循系统性审查的首选报告项目和范围审查的元分析扩展 (PRISMA-ScR) 和乔安娜·布里格斯研究所 (JBI) 的方法.
研究的目的:
- 确定用于修复牙科的材料生物活性的证据范围和类型.
- 系统地审查有关牙科修复材料生物活性的现有文献.
- 识别知识缺口并指导该领域的未来研究.
主要方法:
- 在主要数据库 (PubMed/MEDLINE,Embase,Scopus,Web of Science) 进行了全面的系统搜索,截至2024年5月31日.
- 进行了灰色文献和参考列表搜索,以确保彻底性.
- 纳入标准侧重于实验室和临床研究,研究修复性材料的生物活性,不包括非标准应用的研究.
主要成果:
- 定性分析包括了80项研究,其中绝大多数是体外研究 (63项研究).
- 树脂复合材料和树脂水泥是最常被研究的修复材料.
- 生物活性玻璃和酸 (或纳米酸) 是研究材料中常见的添加剂成分.
结论:
- 据称生物活性牙科复合材料的临床疗效在很大程度上仍未得到证实,因为依赖于体外证据.
- 缺乏使用生物活性修复材料的具体指导方针,阻碍了临床应用.
- 建议使用补充的体外方法来评估生物活性,包括评估酸盐的形成和在牙-物质接口释放的离子.
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