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80岁以上患者的基底细胞癌进行外科切除:临床特征和外科结果
Konstantinos Seretis1, Nikos Bounas1, Erasmia Rapti1
1Department of Plastic Surgery, Medical School, University of Ioannina, 45110 Ioannina, Greece.
Current oncology (Toronto, Ont.)
|March 26, 2025
概括
80岁以上患者的基底细胞癌 (BCC) 呈现更具侵略性,具有更高的复发风险和复杂的病理学. 针对这一老年人群,量身定制的外科手术方法至关重要.
科学领域:
- 皮肤病学 皮肤病学
- 手术瘤学手术瘤学
- 老年医学 老年医学
背景情况:
- 完整的基底细胞癌 (BCC) 切除是标准的,但在80岁以上的患者中,结果未得到充分研究.
- 老年患者往往有并发症和有限的预期寿命,使治疗决策复杂化.
研究的目的:
- 为了研究80岁及以上的个体中BCC的瘤特征和手术结果.
- 为了比较年轻和老年患者队列之间的BCC表现和手术结果.
主要方法:
- 使用前性维护数据库进行观察性队列研究.
- 经组织学确认的BCC接受手术的患者按年龄分组 (<80岁与>80岁).
- 排除患有BCC预易性综合征的患者.
主要成果:
- 1396例BCC病例中有35%发生在80岁以上的患者中;基线特征没有显著差异.
- 老年患者患多种皮肤癌,较大的BCC,高风险区域和被归类为复发高风险的病变的比率更高.
- 在老年人群中,发现了较高的阳性/接近边缘频率,高度亚型和围神经入侵.
- 年龄>80岁,晚期TNM阶段和边缘状态预测了高风险组织学和NCCN复发风险.
结论:
- 在老年人群中,基底细胞癌表现出更具侵略性的特征.
- 这些发现表明,需要针对老年人BCC治疗的个性化手术策略.
关键词:
NCCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN基底细胞癌,基底细胞癌.质细胞 (keratinocyte) 是一种细胞.一个八十岁的八十岁人.复发风险 复发风险 复发风险这是一种外科切除术.治疗治疗治疗治疗治疗治疗
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