患者和医疗保健专业人员对同意向生物银行提供额外的骨髓样本进行研究的反思 - - 一项定性研究
Stuart G Nicholls1, Erika Camilleri2, Taryn Chesser3
1Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.
Current oncology (Toronto, Ont.)
|March 26, 2025
概括
接受急性白血病 (AL) 诊断的患者通常同意研究骨髓 (BM) 样本,受信任和潜在益处的影响. 优化关于疼痛管理和研究价值的信息传递可以改善样本采集.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 生物伦理学生物伦理学
背景情况:
- 在急性白血病 (AL) 诊断期间,对额外骨髓 (BM) 样本的患者同意存在有限的理解.
- 患者的观点对于改善研究样本采集实践至关重要.
研究的目的:
- 探索患者和医疗保健专业人员的经验,同意研究AL的BM样本.
- 确定影响捐赠决策的因素和实践增强的领域.
主要方法:
- 半结构面试对17名为AL治疗的患者 (4-6年前) 和5名医疗保健专业人员进行了半结构面试.
- 实现了数据和,提供了深入的定性见解.
主要成果:
- 患者普遍支持研究,并发现尽管焦虑,但对样本捐献的决策是直接的.
- 关键的决定因素包括感知到的健康影响,家庭支持,疼痛,利他主义和对临床医生的信任.
- 基本信息包括疼痛管理,研究目的和样本安全/隐私.
结论:
- 通过优化信息环境和内容 (疼痛管理,研究价值) 来加强同意过程,可以促进BM研究样本采集.
- 患者的信任和关于样本实用性的明确沟通对于成功参与研究至关重要.
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