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Updated: May 20, 2025

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
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染色体不稳定性与EGFR-TKI耐火性非小细胞肺癌中的cGAS-STING激活有关

Kimio Yonesaka1, Takashi Kurosaki1, Junko Tanizaki1,2

  • 1Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka 589-8511, Japan.

Cells
|March 26, 2025
PubMed
概括

染色体不稳定性 (CIN) 激活了cGAS-STING通路,导致一些非小细胞肺癌 (NSCLC) 患者对表皮生长因子受体氨酸激酶抑制剂 (EGFR-TKI) 的耐药性. 通过逆转促进瘤的变化,阻止这种途径恢复了EGFR-TKI的敏感性.

关键词:
有EGFR突变的非小细胞肺癌.染色体的不稳定性皮肤生长因子受体氨酸激酶抑制剂

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