揭示牙周病和心血管疾病之间的分子交叉声:系统性审查
Gunaraj Dhungana1, Dollada Srisai1, Chethan Sampath1
1Department of Oral Diagnostic Sciences & Research, School of Dentistry, Meharry Medical College, Nashville, TN 37208, USA.
与心血管疾病相关的牙周病涉及特定的细菌和炎症. 了解这些联系对于开发两种疾病的新疗法至关重要.
科学领域:
- 口腔微生物学和免疫学
- 心血管病理生理学心血管病理学
- 系统性炎症 系统性炎症
背景情况:
- 牙周病 (PD) 是一种与全身炎症和心血管疾病 (CVD) 相关的慢性炎症性口腔疾病.
- 口腔失生症,特别是由"红复合体"细菌和Fusobacterium核菌引起的,与PD的发病有关.
- 皮肤病有助于内皮功能障碍,这是心血管疾病发展的关键因素.
研究的目的:
- 系统地审查连接牙周病原体与心血管健康的分子和微生物机制.
- 探索炎症途径,免疫调节和微生物传播如何影响PD-CVD关联.
- 综合目前关于牙周病在心血管疾病进展中的作用的证据.
主要方法:
- 系统的文献审查遵循PRISMA指南.
- 搜索了PubMed和ScienceDirect数据库 (2024年9月至10月) 的PD和CVD研究.
- 在严格的选和资格评估后,包括58篇文章.
主要成果:
- 牙周病原体激活免疫细胞,释放促炎细胞因子 (IL-1,IL-6,TNF-α) 和化学因子 (IL-8,MCP-1).
- 牙周病原体通过TLRs,NF-κB信号和NO失调诱导氧化应激 (ROS) 和全身炎症.
- 生物标志物,如C-反应蛋白,白细胞间蛋白和MMPs,表明与PD和CVD相关的全身炎症反应.
结论:
- 牙周病原体和炎症媒介在全身健康和心血管疾病进展方面发挥着重要作用.
- 基于PD-CVD链接的分子机制需要进一步研究.
- 增强的理解可以推进精准医学和相关疾病的治疗策略.
更多相关视频
08:51Application of Unsupervised Multi-Omic Factor Analysis to Uncover Patterns of Variation and Molecular Processes Linked to Cardiovascular Disease
Published on: September 20, 2024
07:14Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar
Published on: May 30, 2025
相关概念视频
Circadian Rhythms and Gene Regulation
The JAK-STAT Signaling Pathway
Cardiovascular Drugs: Classification based on Therapeutic Indications
Regulation of the Cardiovascular System
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
