摄影生物调节在服用德诺苏马布的患者中:病例报告和文献综述
Gianluigi Caccianiga1, Antonio Barbarisi2, Paolo Caccianiga3
1Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Dentistry journal
|March 26, 2025
概括
光生物调制 (PBM) 可能有利于服用影响骨愈合的药物丹诺苏马布的患者. 虽然缺乏直接研究,但PBM显示出对管理与药物相关的口腔并发症,如与药物相关的骨瘤 (MRONJ) 的承诺.
科学领域:
- 生物医学工程 生物医学工程
- 牙科医学 牙科医学
- 在瘤学瘤学.
背景情况:
- 单克隆抗体丹诺苏马布抑制骨质细胞活动,可能会损害骨愈合.
- 在denosumab患者的骨愈合障碍可能导致口腔并发症,包括与药物相关的骨缩 (MRONJ).
- 光生物调制 (PBM) 正在作为治疗这些口腔并发症的辅助疗法进行研究.
研究的目的:
- 审查有关摄影生物调节疗法对服用denosumab的患者有益的文献.
- 介绍一个用光生物调节疗法治疗的病例报告.
- 探索PBM在管理与登诺苏马布相关的口腔问题的潜在作用.
主要方法:
- 通过PubMed (MEDLINE),Scopus和Web of Science进行了文献搜索.
- 关键词集中在光生物调节疗法和denosumab.
- 审查了25篇文章,并包括一个案例报告.
主要成果:
- 没有研究直接调查PBM的好处,特别是对于denosumab患者.
- 现有的文献支持PBM在治疗MRONJ患者的疗效,这是与denosumab相关的疾病.
- 初步发现表明,PBM对接受德诺苏马布治疗的患者有潜在的益处.
结论:
- 尽管直接证据有限,但PBM显示出作为代诺苏马布治疗口服并发症患者的辅助疗法的前景.
- 将PBM整合到MRONJ管理协议中,代表了治疗策略的进步.
- 需要进一步的研究,以澄清牙细胞,瘤疾病,药物治疗和PBM在康复中的作用之间的关联.
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