超声波增强凝的刺激响应和生物相容的氨衍生水凝
Eduardo Buxaderas1,2, Yanina Moglie1,2,3, Aarón Baz Figueroa2,3
1Instituto de Química del Sur (CONICET-UNS), Departamento de Química, Universidad Nacional del Sur, Av. Alem 1253, Bahía Blanca 8000, Argentina.
Gels (Basel, Switzerland)
|March 26, 2025
概括
超声波显著增强了基于氨的水凝的凝,减少了形成时间和临界凝度. 这些优化的水凝显示出出色的生物相容性和受控的药物释放,使它们成为生物医学应用的前景.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 超分子化学 超分子化学
背景情况:
- 刺激响应的超分子水凝为生物医学用途提供了动态适应性.
- 氨 (Phe) 衍生水凝具有生物相容性,可生物降解性和可调性.
- 优化凝工艺对于快速应用开发至关重要.
研究的目的:
- 为了研究pH和超声波对N替代的Phe衍生物凝的影响.
- 评估超声波在优化水凝形成和性能方面的作用.
- 评估这些水凝对于药物输送应用的适用性.
主要方法:
- 通过还原性氨化和水解合成N替代的Phe衍生物.
- 使用加热-冷却 (H-C) 和加热-超声波-冷却 (H-US-C) 方法形成水凝.
- 评估临界凝度 (CGC),凝动力学,热稳定性,粘弹性,形态学和细胞毒性.
主要成果:
- 两种G1和G2衍生物都显示了H-US-C的增强凝,减少了高达47%的CGC和90%以上的凝时间.
- 超声波诱导的凝表现出更好的网络密度和稳定性,同时保持了热可逆性.
- 细胞毒性研究证实了高生物相容性 (>95%的细胞活力).
结论:
- 超声波是加速和优化超分子凝的强大工具.
- 用超声波制备的基于Phe的水凝显示出增强的特性和快速生物医学应用的潜力.
- 开发的水凝有效地封装和控制5 - 甲和甲铁酸盐等药物的释放,表明作为响应pH的药物递送平台的承诺.
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