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分数CO2激光治疗儿科高成形痕:从过早终止的分裂痕试验中吸取的教训
Sarthak Sinha1, Altay Baykan2,3, Karen Hulin4
1Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada.
使用除式微分CO2激光器 (AFCO2Ls) 进行儿科超性痕 (HTS) 分裂痕试验是具有挑战性的. 招聘困难限制了分析,突出了对HTS干预措施改进试验设计的需要.
科学领域:
- 皮肤病学 皮肤病学
- 整形外科 整形外科 整形外科
- 儿科医学 儿科医学
背景情况:
- 由于痕的演变,评估高缩痕 (HTS) 治疗是复杂的.
- 分裂痕设计可以将治疗效果与自然痕变化隔离开来.
- 在使用分裂痕方法的儿科HTS中,除去分数CO2激光器 (AFCO2Ls) 的证据很少.
研究的目的:
- 评估一个分裂痕设计的可行性,以评估儿童HTS的AFCO2L治疗.
- 确定患有AFCO2Ls的儿科HTS的初步治疗结果趋势.
主要方法:
- 一个从前性分裂痕随机对照试验中改编的可行性试验.
- 患有HTS的儿科患者 (1-17岁) 接受了三次AFCO2L治疗.
- 结果使用温哥华痕量表 (VSS),SCAR-Q和切口仪进行测量.
主要成果:
- 招聘受到COVID-19的严重阻碍,麻醉的担忧,以及对分裂痕方法的低兴趣.
- 只有6名参与者 (9个痕) 被录取,没有达到44个痕的目标.
- 小型,异质的样本大小阻止了有意义的临床结果分析.
结论:
- 这项可行性研究强调了进行严格的儿科HTS研究的困难.
- 招聘和设计方面的挑战需要仔细解释现有证据,考虑到出版偏见.
- 未来的儿科HTS试验需要优化招聘策略和全面的报告,以提高可行性和可靠性.
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