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肥胖诱导的PVAT功能障碍和动脉样硬化发展:GHSR-1a在增加巨细胞透和皮细胞因子分泌中的作用

Sorin Nicolae Peiu^1,2, Florin Zugun-Eloae^3,4, Bogdan Stoica⁵

¹Department of Vascular Surgery, "Grigore T. Popa" University of Medicine and Pharmacy, 16, Universitatii Street, 700115 Iasi, Romania.

Journal of cardiovascular development and disease

|March 26, 2025

概括

巨细胞中生长激素分泌受体 (GHSR) 的增加与肥胖,元炎症和外周动脉疾病 (PAD) 有关. 斑块中的GHSR-1a表达与肥胖症中的炎症标志物和改变的脂蛋白相关.

科学领域:

心血管研究研究心血管研究
代谢综合征是代谢综合征的一种.
免疫学免疫学免疫学

背景情况:

肥胖与超级炎症有关,其中巨细胞的透和组织中的炎症性两极分化有助于疾病.
巨细胞中生长激素分泌受体 (GHSR) 的表达增加与肥胖相关的元炎症有关.

研究的目的:

调查GHSR-1a表达在动脉样硬化斑块和相邻的周围血管脂肪组织 (PVAT) 之间的关联.
探索肥胖和外周动脉疾病 (PAD) 患者GHSR-1a与炎症标志物和脂肪细胞因子概况之间的关系.

主要方法:

对11名患有肥胖和PAD的患者进行重血管化的动脉样硬化斑块和PVAT的分析.
对于巨细胞标记物的免疫组织化学 (CD68,CD80,CD14).
在组织同质物和血清中检测阿迪波涅克丁,素,IL-6和CRP的ELISA.

主要成果:

斑块中具有GHSR-1a阳性巨细胞的患者表现出较高的血清白细胞计数和血小板与淋巴细胞的比率.
在动脉和PVAT同源体中观察到较低的阿迪波内克与莱普的比率和较高的IL-6水平.
研究结果表明,GHSR-1a与增加的巨细胞透和促炎性两极化有关.

结论:

动脉样硬化斑块中的GHSR-1a表达与全身炎症和肥胖症中改变的类细胞因子概况有关.
GHSR-1a可能在斑块内巨驱动的炎症和PAD中的PVAT功能障碍中发挥作用.
准GHSR-1a可能是肥胖相关心血管并发症的潜在治疗策略.

关键词:

这是GHSR-1a.动脉样硬化的斑块格林激素 (ghrelin) 是一种激素.这是一种炎症炎症炎症炎症.巨细胞是一个巨细胞.周围动脉疾病 (PAD)周周脂肪组织 (PVAT)

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