患有非酒精性脂肪肝疾病的患者的心血管表现
Vlad Pădureanu1, Mircea Cătălin Forțofoiu1, Mircea Pîrșcoveanu2
1Department of Internal Medicine, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania.
代谢相关的脂肪肝疾病 (MAFLD) 通过共同的代谢问题和炎症与心血管疾病 (CVD) 有关. 需要进一步的研究来澄清这种联系,并改善患者治疗策略.
科学领域:
- 肝病学和心脏病学.
- 代谢综合征研究 代谢综合征研究
背景情况:
- 非酒精性脂肪性肝病 (NAFLD),现在是代谢相关的脂肪性肝病 (MAFLD),是慢性肝病的主要原因.
- MAFLD与心血管疾病 (CVD) 密切相关,对全球健康负担作出重大贡献.
研究的目的:
- 批判性地审查将MAFLD与心血管疾病联系在一起的病理生理机制.
- 检查共享的代谢障碍,炎症途径和肠道微生物群变化,涉及肝脏和心血管病理.
主要方法:
- 文献综述侧重于目前的证据,将MAFLD与心血管疾病联系起来.
- 分析共享的风险因素,包括胰岛素耐药性,失脂症,炎症和肠道失生症.
主要成果:
- 胰岛素抵抗,脂质失调,全身炎症和肠道失调是将MAFLD与心血管疾病联系起来的关键因素.
- 当前诊断标准的不一致性和缺乏经过验证的非侵入性生物标志物阻碍了对因果关系的理解.
结论:
- 标准化诊断协议和大规模纵向研究对于解决知识差距至关重要.
- 改进的生物标志物验证和机制理解将增强心血管风险分层和MAFLD患者的个性化疗法.
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