在心房的性别差异:循环代谢物的证据循环代谢物
Ningjing Qian1,2,3, Junyan Jin1,2,3, Ying Gao1,2,3
1Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
在心房 (AF) 中的性别差异与特定的循环代谢物有关. 黄酸在男性中较高,有助于AF的发展和左心房重塑.
科学领域:
- 心脏病学 心脏病学
- 代谢学 代谢学 代谢学
- 疾病中的性别差异.
背景情况:
- 心房动 (AF) 在患病率和机制上表现出严重的基于性别的差异.
- 了解这些性别差异对于改善AF管理策略至关重要.
- 循环中的代谢物代表着影响性别特异性AF病变的潜在因素.
研究的目的:
- 调查循环代谢物在心房中观察到的性别差异中的作用.
- 以性别特定的方式识别与AF风险和左心房重塑相关的特定代谢物.
- 探索将已识别的代谢物与AF病理生理学联系起来的分子机制.
主要方法:
- 从男性和女性AF患者的血中进行非向的代谢学分析.
- 相关性分析和门德尔随机化以确定特定性别的AF相关代谢物.
- 左心房组织的转录组分析和对心肌细胞的体外研究.
主要成果:
- 60个注释的代谢物显示男性和女性AF患者之间的水平差异.
- 苏辛酸,7-甲基瓜诺辛和N-Undecylbenzenesulfonic酸与左心房重塑相关.
- 较高的酸水平与增加AF风险 (OR=1.26) 和男性左心室上调的SUCLA2基因表达有关.
结论:
- 这项研究揭示了男性和女性AF患者不同的循环代谢物概况.
- 酸成为一个关键的性别特异性代谢物,有助于AF的发病,特别是在男性中.
- 顺酸促进心肌细胞增大和线粒体功能障碍,突出其在AF进展中的作用.
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