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Updated: May 20, 2025

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外部验证危险预测评分为候群病在重症患者:一个回顾性观察性研究
Nurul Mazni Abdullah1, Saw Kian Cheah1, Raha Abdul Rahman1
1Department of Anesthesiology and Intensive Care, Hospital Canselor Tuanku Muhriz, Jalan Yaacob Latiff, Andar Tun Razak, Cheras, Kuala Lumpur 56000, Malaysia.
Journal of fungi (Basel, Switzerland)
|March 26, 2025
概括
这项研究发现,一个常见的风险预测得分更好地排除候群血症 (血流真菌感染),而不是预测危急病患者的情况. 它不应该作为唯一的诊断工具.
科学领域:
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
- 流行病学 流行病学
背景情况:
- 血流真菌感染的 кандидемия 与重症患者的高死亡率有关.
- 及时诊断候选血症对于有效的治疗启动至关重要.
- 现有的风险预测得分需要外部验证来评估其临床效用.
研究的目的:
- 在重症患者群体中对候选血病风险预测得分进行外部验证.
- 在重症监护室 (ICU) 设置中识别出血病的独立风险因素.
主要方法:
- 追溯性观察性研究,对500名入院到第三级转诊中心的重症监护室的重症患者进行了观察.
- 从2018年1月到2023年12月收集的数据.
- 使用双变量和多变量回归分析来评估风险因素和患者的结果.
主要成果:
- кандидеми的发生率为8.86%. 关节营养和Candida殖民被确定为独立的危险因素.
- 经验证的风险预测得分显示灵敏度为75.0%,特异性为65.4%,NPV为96.4%,PPV为17.3%.
- 淋病患者的SOFA分数更高,ICU和住院时间更长,ICU和住院死亡率增加.
结论:
- 研究的风险预测得分更有效地排除了候选血症,而不是预测其发生.
- 评分的低正预测值限制了其作为唯一诊断指南的实用性.
- 临床判断和进一步的诊断测试对于管理疑似候选血症至关重要.
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