聚乙烯微塑料可以加剧由酸引起的肠道微环境损伤:一种流行的藻类毒素
Hong-Jia Huang1, Yang Liu1, Da-Wei Li1
1Key Laboratory of Aquatic Eutrophication and Control of Harmful Algal Blooms of Guangdong Higher Education Institute, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
Marine drugs
|March 26, 2025
概括
对微塑料 (MP) 和酸 (OA) 的同时暴露会损害肠道细胞并破坏肠道细菌. 这种联合暴露给健康带来了重大风险,影响了肠道平衡和潜在的公共安全.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 微生物学 微生物学
背景情况:
- 微塑料 (MP) 是新兴的污染物,具有潜在的人类健康风险.
- 酸 (OA) 是一种海洋毒素,会引起胃肠道问题.
- 同时暴露于MP和OA可能会加剧健康风险和公共安全问题.
研究的目的:
- 研究MPs和OA共同暴露对肠道微环境的毒性机制.
- 评估对人类Caco-2细胞和体外便发酵的影响.
主要方法:
- 利用人类的Caco-2细胞作为肠道模型.
- 进行了体外便发酵实验.
- 评估了细胞活力,活性氧物种 (ROS),乳酸脱酶 (LDH) 释放,ABC载体活性,OA积累和炎症反应.
主要成果:
- 同时暴露于MPs (80μg/mL) 和OA (20 ng/mL) 降低了细胞活力,增加了ROS的产生和LDH的释放.
- 观察到ABC载体活性受损,促进了OA的积累,并触发了炎症反应.
- 肠道微生物组成被破坏,有益细菌减少,机会性病原体增加,如Escherichia-Shigella.
结论:
- 同时暴露于MP和OA会损害肠道上皮质的完整性.
- 这些发现强调了与MP和OA联合暴露相关的潜在健康风险.
- 提供了对肠道平衡和潜在机制影响的新见解.
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