纤维素原与碳酸以乳液为基础的封装用于控制出血
Henry T Peng1, Tristan Bonnici1, Yanyu Chen2
1Defence Research and Development Canada, Toronto Research Centre, Toronto, ON M3K 2C9, Canada.
Journal of functional biomaterials
|March 26, 2025
概括
使用水-油-水方法创建了新的纤维素-碳酸 (CaCO3) 颗粒,以改善严重出血的静血剂. 这些颗粒显示出增强的自我推进和纤维素素的结合,推进创伤护理.
科学领域:
- 生物材料科学 生物材料科学
- 血液静止和血栓形成
- 创伤医学 创伤医学
背景情况:
- 非压缩性干出血是创伤患者可预防死亡的主要原因.
- 现有的自行驱动血静止器使用碳酸 (CaCO3) 微粒和酸 (TXA+) 在动物模型中显示出有前途.
- 提高这些药物的静血和自动推进性质对于改善创伤护理至关重要.
研究的目的:
- 研究使用水-油-水 (W/O/W) 乳液方法制备纤维原-碳酸 (CaCO3) 颗粒.
- 为了增强创伤止血剂的静血和自动推进能力.
- 描述制备条件对颗粒产量,大小和纤维素含量的影响.
主要方法:
- 通过W/O/W乳液技术制造纤维素-CaCO3颗粒.
- 使用光和光显微镜,凝电泳,旋转血栓前膜造影 (ROTEM) 和视频运动跟踪进行表征.
- 评估颗粒产量,大小,纤维素含量,静血效应和自我推进能力.
主要成果:
- 该W/O/W方法产生了球形,微米大小的纤维素-CaCO3颗粒,其产量和纤维素含量可变.
- 颗粒大小与纤维素含量正相关;不同的碳酸盐来源和油相影响了颗粒大小和产量.
- 纤维素包装的颗粒在与TXA+和血-CaCO3颗粒相结合时表现出静血效应和协同活性,在水中表现出自我推进.
结论:
- 在W/O/W乳液方法成功地产生了带有增强的纤维素合并和自我推进的纤维素-CaCO3颗粒.
- 这些新型颗粒代表了血液静止技术的进步,用于控制严重的出血.
- 对封装过程的进一步优化有可能提高纤维素-CaCO3颗粒在临床创伤环境中的有效性.
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