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卵巢作为新一代双的目标器官毒性双

Paulina Głód^1,2, Joanna Smoleniec^1,2, Weronika Marynowicz^1,2

¹Laboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Gronostajowa 9, PL30387 Cracow, Poland.

|March 26, 2025

概括

双 (BPs),包括BPA及其类似物如BPS和BPF,是环境和人体样本中发现的内分泌干扰剂. 这些化学物质对卵巢功能构成风险,影响卵巢生成,卵泡生成和类固醇生成.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
生殖生物学生殖生物学

背景情况:

双 (BPs) 广泛用于塑料和树脂,引起了人们对其内分泌干扰作用的担忧.
双A (BPA) 被广泛研究,导致监管行动;然而,它的类似物 (BPS,BPF等) 越来越多地被用作替代品.
这些BP及其类型在环境介质和人体样本中被检测到,这表明暴露范围广泛.

研究的目的:

审查关于双醇对卵巢的影响的当前知识.
阐明双醇诱导卵巢毒性的机制.
强调双对生殖功能的影响,并强调需要进行生物安全评估.

主要方法:

关于双暴露和卵巢毒性研究的文献综述.
对双醇对 oogenesis,folliculogenesis 和 steroidogenesis 的作用机制的研究分析.
综合环境和生物样本中双醇存在的数据,包括人类毛囊液.

主要成果:

双,包括BPS和BPF等类似物,在环境样本和人体尿液中被检测到显著水平.
在人类的卵泡液中发现了BP,这表明对卵巢功能有潜在的膜效应.
有证据表明,双可以对卵巢的关键过程产生负面影响,如卵巢生成,卵泡生成和类固醇生成.

结论:

双暴露对卵巢功能和生殖健康构成风险.
由于BP的广泛存在和内分泌干扰性,需要对其生物安全性进行进一步的研究.
持续监测和研究对于理解和减轻与双暴露相关的生殖健康风险至关重要.

关键词:

双醇是一种双醇.破坏内分泌的化学物质破坏内分泌的化学物质生育能力生育能力生育能力生育能力毛囊液体毛囊液体毛囊液体毛囊细胞生成 (Folliculogenesis) 是一种眼睛的生成眼睛的产生卵巢卵巢是一个卵巢.生殖系统疾病生殖系统疾病类固醇受体类固醇受体类固醇的产生.

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