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会通过损害体功能和丸塞尔托利细胞的自流引起脂质滴积累
Chengwei Guo1, Lingqiao Wang1, Ke Cui1
1Department of Environmental Health, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing 400038, China.
Toxics
|March 26, 2025
概括
暴露于会通过破坏细胞废物清除 (自) 来损害男性生育能力. 这导致生殖细胞中有毒脂质的积累,但向自成熟可能提供治疗解决方案.
科学领域:
- 环境毒理学环境毒理学
- 生殖生物学 生殖生物学
- 细胞生物学 细胞生物学
背景情况:
- (Pb) 是一种广泛存在的环境污染物,已知对男性生殖健康有不良影响.
- 导致引起的生殖毒性背后的精确分子机制尚不清楚.
研究的目的:
- 研究毒性对男性生殖健康的分子机制,专注于自.
- 探索引起的男性生殖器损伤的潜在治疗干预措施.
主要方法:
- 雄性ICR小鼠被暴露在饮用水中的不同度的中90天.
- 评估了精子质量,与自相关的蛋白质水平,溶酶体功能和脂质滴积累.
- 评估了TFE3基因表达和氨酸,巴菲洛米辛A1和N-乙半氨酸 (NAC) 的作用.
主要成果:
- 暴露于,特别是300毫克/升,降低了精子质量,增加了小鼠丸中的自蛋白.
- 损害了 lysosomal 功能,阻碍了自清除,并导致 Sertoli 细胞中的脂质滴积累.
- 由激活TFE3影响了自细胞形成,而NAC通过增强自减轻了的毒性作用.
结论:
- 暴露于会破坏自流,导致脂质滴积累和男性生殖毒性.
- 与自成熟阶段的干扰是毒性的关键机制.
- 准自成熟过程是一个潜在的治疗策略,可以预防引起的男性生殖损伤.
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