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病例报告:从侵袭性牙周炎转变为猫类慢性牙周炎与增加的微生物多样性有关

Claire A Shaw¹, Maria Soltero-Rivera², Rodrigo Profeta¹

¹Department of Population Health and Reproduction, 100 K Pathogen Genome Project, University of California, Davis, CA 95616, USA.

Pathogens (Basel, Switzerland)

|March 26, 2025

概括

随着攻击性牙周炎 (AP) 进展为猫类慢性牙周炎 (FCGS),口腔微生物组发生了显著的变化. 增加的微生物多样性和改变的基因表达表明这些猫类口腔炎症疾病之间存在潜在联系.

科学领域:

兽医医学兽医医学兽医医学
微生物学微生物学
基因组学就是基因组学.

背景情况:

侵袭性牙周炎 (AP) 和猫类慢性牙周炎 (FCGS) 是猫的严重口腔炎症状况,原因不明.
口腔微生物组在AP和FCGS进展中的作用尚不清楚.
了解这些微生物转变对于开发诊断和治疗方法至关重要.

研究的目的:

在猫模型中,研究在AP向FCGS进展期间口腔微生物组的纵向变化.
分析口腔微生物群体中的分类学和功能性转变.
识别与疾病进展相关的潜在微生物生物标志物.

主要方法:

从单一猫的纵向口腔微生物组样本的深度元基因组和元转录组测序.
在属和物种层面分析微生物多样性.
检测抗微生物耐药性 (AMR) 基因和毒性因子的表达.

主要成果:

在从AP过渡到FCGS时,观察到口腔微生物多样性 (属和物种水平) 的显著增加.
特定的细菌属,包括*Porphyromonas*和*Treponema*,增加,而*Streptobacillus*减少.
与疾病相关的基因 (*cheY*, *ompP5*, *galU*) 和与疾病状态相关的AMR/病毒性因子的差异表达.

结论:

口腔微生物组的分类学和功能转变伴随着猫从AP向FCGS的进展.
这些发现表明,由微生物变化驱动的AP和FCGS之间存在潜在的联系.
鉴定到的微生物和功能变化可能会为开发新的基于微生物的诊断和治疗猫咪口腔疾病的治疗提供信息.

关键词:

攻击性的牙周炎.猫类慢性牙周牙周炎.转换组学转换组学转换组学微生物社区的微生物社区.口腔微生物组是口腔的微生物组.

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