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普遍治疗作为预防加上专注的暴露前预防是控制艾滋病毒/艾滋病的关键

Julio S G Montaner^1,2, Viviane D Lima^1,2, Kate A Salters^1,2

¹British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC V6Z 1Y6, Canada.

Tropical medicine and infectious disease

|March 26, 2025

概括

将治疗作为预防 (TasP) 和暴露前预防 (PrEP) 结合起来,可显著减少艾滋病毒的传播. 这种协同方法加速了结束艾滋病毒/艾滋病流行病的进展.

科学领域:

公共卫生公共卫生
流行病学流行病学
传染病控制和控制传染病

背景情况:

治疗作为预防 (TasP) 和暴露前预防 (PrEP) 是控制艾滋病毒/艾滋病的关键生物医学策略.
塔斯普涉及艾滋病毒感染者 (PLWH) 的立即抗逆转录病毒疗法 (ART),防止艾滋病的进展和传播.
在高风险,坚持 PrEP 的人群中,提供了预防艾滋病毒感染的保护.

研究的目的:

评估不列颠哥伦比亚省"通用TasP+专注PrEP"计划对减少艾滋病毒传播的协同影响.
评估TasP和PrEP在控制HIV有效生殖数 (Re) 的联合有效性.

主要方法:

在不列颠哥伦比亚省实施了"通用TasP+专注PrEP"计划,持续了20年.
长期监测社区血病毒载量 (pVL) 抑制TasP有效性.
监测高风险人群中的艾滋病毒发病率,以确定PrEP的有效性.

主要成果:

综合的"通用TasP+专注PrEP"计划在降低艾滋病毒有效生殖率方面表现出协同效应 (Re).
通过病毒载量抑制,TasP通过降低可传染性艾滋病毒池来降低艾滋病毒发病率.
在敏感个体中,PrEP减少了新感染,这与病毒载量抑制无关.

结论:

通用TasP和集中PrEP的结合是控制艾滋病毒/艾滋病的高度有效策略.
强烈支持这种综合方法的广泛实施.
持续对Re的程序性监测对于优化TasP和PrEP计划以及实现全球艾滋病毒/艾滋病消除目标至关重要.

关键词:

艾滋病毒控制战略艾滋病毒控制策略艾滋病毒流行病学艾滋病毒流行病学预防艾滋病毒传播预防艾滋病毒传播艾滋病毒治疗级联.预防艾滋病毒/艾滋病的预防暴露前预防 (PrEP) 治疗作为预防的治疗 (TasP)抗逆转录病毒治疗 (ART)公共卫生和艾滋病毒/艾滋病.针对艾滋病毒的有针对性的干预措施.

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