与crizotinib相关的肝脏和囊:一个病例报告与MRI发现
Saki Yamamoto1, Toshimi Kawahata2, Sota Masuoka3
1Department of Radiology, Jichi Medical University, Shimotsuke, Japan. r1837ms@jichi.ac.jp.
Abdominal radiology (New York)
|March 26, 2025
概括
对ROS1阳性肺癌的克里佐替尼治疗可能会导致脏和肝脏囊. 典型的MRI发现可能有助于区分这些药物诱导的囊与其他疾病.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 药理学 药理学是指药理学的学科.
背景情况:
- 克里佐替尼是针对ROS1融合阳性非小细胞肺癌的向治疗.
- 药物诱导的器官毒性可以以各种方式表现,包括囊性病变.
- 从临床上来说,区分药物诱导的囊与转移或等其他病理是非常重要的.
研究的目的:
- 报告一个与crizotinib相关的脏和肝脏囊病例.
- 描述这些囊的特征磁共振成像 (MRI) 发现.
- 突出MRI在区分这些囊方面的潜在诊断效用.
主要方法:
- 一个患有ROS1融合阳性肺腺癌的病人用crizotinib治疗的病例报告.
- 临床表现包括发烧,腹痛和寡尿症.
- 用对比度增强的计算机断层扫描 (CT) 和MRI进行病变特征化.
- 皮肤通道囊排水和细胞学.
- 在停止使用crizotinib后进行后续成像.
主要成果:
- 在crizotinib治疗期间,脏和肝脏出现多种囊性病变.
- CT显示有厚壁和超密度的囊性病变.
- 核磁共振显示异质信号强度,T2低强度/T1高强度区域沿囊壁,以及外周扩散限制.
- 细胞检测显示有炎症细胞,但没有恶性或微生物.
- 在停止使用crizotinib后观察到囊回归.
结论:
- 克里佐替尼可以诱导ROS1融合阳性肺癌患者的脏和肝脏囊形成.
- 特定的MRI发现,包括T2低压/T1高强度沿囊壁和外周扩散限制,暗示有crizotinib相关的囊.
- 这些特征性的MRI发现可能有助于区分crizotinib诱导的囊与转移和.
- 这是第一份报告详细介绍了crizotinib相关的肝囊的MRI发现.
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