PUNCH2:.

Di Meng1, Gianluca Pollastri1

  • 1School of Computer Science, University College Dublin, Dublin, Ireland.

PloS one
|March 26, 2025
PubMed
概括

新的预测器,PUNCH2和PUNCH2-light,可以准确地识别内在无序的蛋白质 (IDP) 和它们的区域 (IDR). 这些工具利用先进的功能和神经网络,在最近的比赛中表现优于其他人.

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The native conformation of a protein is formed by interactions between the side chains of its constituent amino acids. When the amino acids cannot form these interactions, the protein cannot fold by itself and needs chaperones. Notably, chaperones do not relay any additional information required for the folding of polypeptides; the native conformation of a protein is determined solely by its amino acid sequence. Chaperones catalyze protein folding without being a part of the folded protein.
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