努西费林对缺血-再输液损伤后的功能障碍的影响
Sundus M Sallabi1, Loay Lubbad1, Harun R Toumi1
1Department of Surgery, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
PloS one
|March 26, 2025
概括
努西费林是一种天然化合物,可以保护脏免受因缺血-再输液损伤 (IRI) 造成的损伤. 这项研究表明,努西费林显著改善功能,并减少脏IRI的老鼠模型中的损伤标志物.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
背景情况:
- 缺血-再输损伤 (IRI) 是移植和低血压复苏的关键并发症,导致立即功能障碍和潜在的长期损伤.
- 缓解IRI对脏的有害影响是一个重大的临床挑战.
- 自然化合物越来越多地在各种疾病中探索其治疗潜力.
研究的目的:
- 为了研究核素的保护作用,一种植物化学物质来自Nelumbo nucifera Gaertn.
- 为了评估努西费林对功能障碍和组织学损伤在IRI的老鼠模型的影响.
主要方法:
- 努西费林 (30毫克/公斤/天口服) 给老鼠服用,IRI前9天和IRI后3天.
- 一个双边温暖的缺血模型被诱导了35分钟.
- 评估了功能 (血清肌素,尿素,肌素清除率,尿路白素-肌素比率) 和组织学变化.
主要成果:
- 努西费林显著减弱了IRI诱导的血清肌素和尿素的增加,并改善了肌素清除和尿白蛋白-肌素比率.
- 努西费林的使用减少了损伤标志物,促炎性,促纤维性和促性细胞因子.
- 组织学检查显示,在接受努西费林治疗的老鼠中,损伤显著减弱.
结论:
- 努西费林在老鼠中显示出显著的保护作用,防止IRI诱导的功能障碍.
- 这些发现表明,努西费林在治疗脏IRI方面具有潜在的临床效用.
- 对努西费林的机制和临床应用的进一步研究是有必要的.
相关概念视频
Imbalances in Cardiac Output
3.3K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
3.3K
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
382
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
382
Hemodialysis II: Procedure and Complications
2.2K
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
2.2K
Hemorrhagic Stroke ll: Pathophysiology
30
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
30
Cerebral Edema l: Introduction
30
Cerebral edema is a pathological increase in brain water content that disrupts intracranial pressure regulation and impairs neurological function. Because the cranial vault is rigid, even modest increases in tissue volume can compromise cerebral perfusion, distort neural structures, and initiate secondary injury. Cerebral edema develops through four principal mechanisms: vasogenic, cytotoxic, interstitial, and ionic.Vasogenic EdemaVasogenic edema arises from disruption of the blood–brain...
30
Secondary Spinal Cord Injury llI: Pathophysiology
52
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
52


