对癌症预后中的加勒-9表达的新见解:更新的系统性综述和元分析
Chun Yan So1, Yusong Li1, Kwan Ting Chow1
1Department of Biomedical Sciences, City University of Hong Kong, Kowloon, Hong Kong SAR.
PloS one
|March 26, 2025
概括
加勒-9 (Gal-9) 作为癌症的预后标记物显示出前景. 高的Gal-9表达预测了固体瘤的更好的生存率,但在血液癌症的结果更差,突出了特定背景的角色.
科学领域:
- 癌症免疫学 癌症免疫学
- 瘤微环境是一个微环境.
- 免疫治疗是一种免疫疗法.
背景情况:
- 瘤微环境中的加勒-9 (Gal-9) 相互作用会影响癌症的进展.
- -9在瘤细胞中的预后意义尚不清楚,关于表达水平和患者结果的数据相矛盾.
研究的目的:
- 进行综合性审查和元分析,以确定Gal-9表达在各种癌症类型中的独立预后作用.
- 研究Gal-9表达对癌症亚型的不同影响及其作为预后标记物的潜力.
主要方法:
- 在PubMed,Embase和Web of Science的系统数据库搜索中进行了2024年12月之前发表的研究.
- 使用95%置信区间 (CI) 的聚合危险比率 (HRs) 来评估Gal-9表达在预测癌症结果中的作用.
- 分析包括29项研究,包括4720名患者.
主要成果:
- 增加的Gal-9表达与固体瘤的整体存活率 (OS) 的改善显著相关 (HR = 0.75,95%CI:0.63-0.90,p = 0.002).
- 高高的Gal-9表达与血液癌症中更快的疾病进展相关 (HR = 2.29,95% CI: 1.26-4.16,p = 0.007).
- 亚组分析表明,Gal-9表达与胃肠道和泌尿系统癌症的OS有关,以及肝胆道和泌尿系统癌症的DFS/RFS.
结论:
- 加勒-9是固体瘤的有希望的预后指标,高表达与特定癌症类型的更好的预后有关.
- 相反,血液癌的高Gal-9表达与较差的结果有关,这强调了对特定环境生物标志物解释的需要.
- 该研究强调了Gal-9在癌症进展中的多样性作用,影响细胞内和分泌功能.
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