使用冷却包,以减少皮下注射疫苗的疼痛在3-6岁的儿童:一个单盲,随机,平行组多中心研究
Ikuo Okafuji1, Ryuta Washio2, Takao Okafuji3
1Department of Pediatrics, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan.
PloS one
|March 26, 2025
概括
当地冷却有效地减少了儿童疫苗接种期间的疼痛. 这种简单的方法可以提高3-6岁儿童接受日本脑炎或流感等疫苗的舒适度.
科学领域:
- 儿科医学 儿科医学 儿科医学
- 疼痛管理 疼痛管理
- 接种疫苗的技术.
背景情况:
- 儿童疫苗接种的基于证据的止痛方法存在,但往往是劳动密集型的.
- 这些疼痛管理策略的常规临床应用是有限的.
研究的目的:
- 评估局部冷却在幼儿皮下疫苗注射期间减轻疼痛的安全性和有效性.
- 为儿童疫苗接种提供一种实用,易于实施的缓解疼痛的选择.
主要方法:
- 一个单盲,随机的多中心研究,涉及60名接受疫苗接种的学龄前儿童 (3-6岁).
- 参与者被分配到局部冷却组 (注射前冷却包) 或对照组.
- 通过视频分析,使用FLACC尺度 (面部表情,腿部运动,活动,哭泣,安慰) 测量疼痛.
主要成果:
- 与未冷却组相比,冷却组的FLACC疼痛评分中位数明显较低 (1 [IQR 0-1.25]) (2.5 [IQR 1-6]),P=0.011.
- 没有报告与局部冷却方法相关的不良影响.
- 该研究包括针对日本脑炎和流感的疫苗接种.
结论:
- 局部冷却是一种安全有效的干预措施,用于减少3-6岁儿童在皮下接种疫苗时的疼痛.
- 这种技术提供了一种实际的方法,可以在常规免疫接种期间提高患者的舒适度.
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