收回的与未收回的产科随机试验:哪些质量标准与收回不可靠性最相关?
Sarah Lawson1, Georgios Doulaveris2, Kathryn Anderson3
1Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, United States.
概括
一个新的质量检查清单有助于识别撤回的研究. 收回的随机对照试验 (RCT) 显示质量标准的遵守程度较低,这有助于期刊防止发表欺诈性研究.
科学领域:
- 医学研究诚信 医学研究诚信
- 科学出版标准 科学出版标准
- 产科和妇科研究研究 产科和妇科研究
背景情况:
- 随机对照试验 (RCT) 对医学知识至关重要,但由于不当行为而导致的撤回威胁到科学完整性.
- 科学界寻求强有力的质量标准,以提高发表的研究的可信度.
- 确保RCT的可靠性对于准确的系统审查和元分析至关重要.
研究的目的:
- 评估新开发的质量标准检查清单在将收缩和非收缩产科RCT区分开来时的有用性.
- 确定特定的质量标准,这些标准在撤回和非撤回研究之间有显著差异.
- 为同行评审期刊提供可操作的见解,以改善手稿评价流程.
主要方法:
- 通过专家协商一致制定了一份质量标准清单.
- 通过Retraction Watch数据库确定了收缩的产科RCT (1994-2024年).
- 非撤回的产科RCT (2018-2020年) 作为对照;两组都被评估是否遵守检查清单.
主要成果:
- 总共分析了173项研究 (37项已撤回,136项未撤回).
- 两组之间在17个质量标准中的13个 (76.5%) 中观察到显著差异.
- 在≤11个总质量标准的截止值中,在识别收回的研究中,显示出高灵敏度 (94.9%) 和特异性 (78.4%).
结论:
- 与未被撤回的研究相比,被撤回的研究对17个质量标准清单的遵守率明显较低.
- 检查清单为同行评审期刊提供了宝贵的见解,可以在出版之前仔细审查RCT手稿.
- 期刊编辑应优先考虑与研究伦理,数据伪造和偏见风险相关的评估标准.
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