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在现场形成AIEgen-alginate水凝,用于重塑瘤微环境,以促进FLASH免疫放射治疗

Meng Lyu¹, Tianfu Zhang², Zhirong Bao³

¹Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, 518020, China.

|March 26, 2025

概括

这项研究引入了一种AIEgen-alginate水凝,以增强FLASH放射治疗和光动力学疗法 (PDT) 的结肠癌治疗. 这种新的方法诱导免疫细胞死亡,增强抗瘤免疫力,并防止瘤复发.

科学领域:

在瘤学瘤学.
生物医学工程生物医学工程
材料科学材料科学材料科学

背景情况:

闪光辐射疗法提供了快速的瘤切除,但由于免疫抑制性瘤微环境 (TME) 导致的瘤细胞杀死不完全面临挑战.
TME可能会阻碍晚期癌症治疗的疗效,需要制定克服其免疫抑制作用的策略.

研究的目的:

开发一种基于水凝的新型系统,使结肠癌对FLASH放射治疗和光动力学疗法 (PDT) 敏感.
调查结合聚合诱导排放光原体 (AIEgen) -酸盐水凝与PDT和FLASH放射治疗以增强抗瘤免疫力的潜力.

主要方法:

用AIEgen (CQu) 合的花样碳酸纳米颗粒的设计,并与酸盐结合,在酸性TME中形成局部水凝 (FA).
使用FA水凝在TME中捕获CQu,然后进行激光照射以诱导持续的活性氧物种 (ROS) 生产.
用单次注射FA水凝,然后进行PDT和FLASH放射治疗,以诱导免疫性瘤细胞死亡.

主要成果:

开发的水凝系统有效地产生了持续的ROS产量,并诱导了Ca2+过载,导致癌细胞中的线粒体损伤.
使用FA水凝,PDT和FLASH放射治疗的联合治疗成功诱导了免疫性瘤细胞死亡.
该疗法促进了抗瘤免疫力,防止瘤复发,并显示出了腹效应.

结论:

该AIEgen-alginate水凝系统显示出显著的潜力,可以提高FLASH放射治疗和PDT治疗结肠癌的疗效.
持续的ROS生产和Ca2+过载是改善瘤细胞对FLASH放射治疗的敏感性和实现最佳免疫治疗结果的关键机制.
这种创新方法为克服TME介导的免疫抑制和提高癌症治疗疗效提供了一个有希望的策略.

关键词:

聚合诱导排放的发光剂 (AIEgen)结肠癌是什么意思结肠癌是什么意思闪电免疫放射疗法 (FLASH) 是一种免疫放射疗法.在现场凝凝.瘤微环境是一个微环境.

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