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继承牛淋巴细胞肠保留缺陷障碍影响霍尔斯坦的生产表现和寿命
A Al-Khudhair1, D J Null1, P M VanRaden1
1USDA, Agricultural Research Service, Animal Genomics and Improvement Laboratory, Beltsville, MD 20705-2350.
Journal of dairy science
|March 26, 2025
概括
新的方法可以追踪牛体淋巴细胞肠保留缺陷 (BLIRD) 突变. 盲鸟类同胞体显示出小母牛的生存能力和产量特征显著降低,造成了相当大的经济损失. 基因测试对于管理这些新突变至关重要.
科学领域:
- 动物遗传学 动物遗传学
- 畜牧养殖 畜牧养殖 畜牧养殖
- 定量遗传学 是一种定量遗传学.
背景情况:
- 扩展了用于跟踪胆固醇缺乏 (HCD) 和肌肉虚弱 (HMW) 类别突变的改进方法.
- 牛淋巴细胞肠保留缺陷 (BLIRD) 最近在法国被发现.
研究的目的:
- 将现有的突变追踪方法应用于BLIRD.
- 用美国数据估计BLIRD同胞体的衰退效应,并与法国估计进行比较.
- 评估BLIRD对牲畜的经济影响.
主要方法:
- 利用了来自300万个具有美国表型的基因型动物的哈普洛型状态.
- 采用动物模型来估计BLIRD同卵性对母牛生存能力的影响.
- 计算的产量特征效应 (牛奶,脂肪,蛋白质) 和BLIRD同胞的终身净价值成本.
主要成果:
- BLIRD同胞的表现是母牛生存能力降低 (代码2的8.6%,代码4的3.3%).
- 产量特征受到显著影响: -1,799公斤牛奶, -63公斤脂肪, -55公斤蛋白质每同卵子,成本为1,206美元.
- 在8.9%的等位基频率人口中随机交配一只BLIRD载体导致每次交配的经济损失估计为74美元.
结论:
- 由于生活和生产能力下降,BLIRD对畜牧业构成重大经济威胁.
- 目前的基因组预测可能无法完全解释新突变造成的损失.
- 开发和实施基因测试,以检测常见单个类型中的新突变,对于有效的管理和育种策略至关重要.
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