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内皮细胞miR-34a的删除防止了动脉瘤的发展,尽管内皮细胞功能障碍.

Aleksandra Kopacz1, Damian Kloska1, Anna Bar2

  • 1Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.

Biochimica et biophysica acta. Molecular basis of disease
|March 26, 2025
PubMed
概括

微RNA-34a (miR-34a) 通过调节NRF2驱动内皮细胞衰老和腹腔大动脉动脉瘤 (AAA) 的发展. 抑制miR-34a可以防止AAA,这表明它具有治疗潜力.

关键词:
腹腔大动脉动脉瘤 腹腔大动脉动脉瘤内皮细胞是内皮细胞.内皮质功能障碍 内皮质功能障碍这就是NRF2的NRF2.在 miR-34a 中使用.

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