血清25-基维生素D和完整的副甲状腺激素作为早期儿童骨质的功能生物标志物
Karen M O'Callaghan1, Celine Funk2, Farzana Fariha3
1Department of Nutritional Sciences, King's College London, London, United Kingdom.
The Journal of nutrition
|March 26, 2025
概括
在幼儿中,维生素D缺乏不是由骨质量来定义的. 然而,建议维持25-基维生素D (25(OH) D) 水平在25nmol/L以上,以抑制副甲状腺激素 (PTH).
科学领域:
- 儿科内分泌学 儿科内分泌学
- 营养科学 营养科学
- 骨的健康 骨的健康
背景情况:
- 抑制副甲状腺激素 (PTH) 的25-氧维生素D (25(OH) D水平用于定义维生素D缺乏症.
- 关于这一值与幼儿骨质相关性的数据有限.
研究的目的:
- 为了确定PTH抑制的25(OH) D值是否与幼儿的骨矿物质含量 (BMC) 和骨矿物质密度 (aBMD) 相对应.
- 在4岁儿童中调查25-OH-D,PTH和骨健康结果之间的关系.
主要方法:
- 对孟加拉国534名儿童的BONUSKids研究数据的二次分析.
- 使用LC-MS/MS和化学发光免疫试验测量血清25(OH) D和完整的PTH (iPTH).
- 通过DXA评估的BMC和aBMD;使用多变量回归和脊柱模型建模的关联.
主要成果:
- 在25nmol/L时观察到25(OH) D和iPTH关系的拐点,在这个水平以下有更强的反向关联.
- 在PTH水平和骨结果之间没有发现显著的关联.
- 25 (((OH) D和骨质结局之间的正线性关联是单调的.
结论:
- 根据骨质量定义维生素D缺乏症的A 25 ((OH) D值在4岁的孟加拉儿童中没有被确定.
- 由于其与PTH抑制的关联,建议维持25OH) D水平在25nmol/L或以上.
- 这项研究在clinicaltrials.gov上注册为#NCT03537443.
关键词:
25氧维生素D是一种25-氧维生素.孟加拉国 孟加拉国 孟加拉国骨矿物质含量 骨矿物质含量骨矿物质密度 骨矿物质密度孩子孩子孩子孩子孩子孩子低收入和中等收入国家.甲状腺上腺激素激素的作用维生素D是维生素D的重要组成部分.更多相关视频
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