更新的复发后存活结果在患者接受多切除术/脱皮为多间皮瘤:一个回顾性研究
Akifumi Nakamura1, Masaki Hashimoto1, Ayumi Kuroda1
1Division of Thoracic Surgery, Department of Surgery, Hyogo Medical University, Hyogo, Japan.
The Annals of thoracic surgery
|March 26, 2025
概括
接受复发后治疗,局部复发,年龄在70岁以下,经过超过12个月的无病间隔的多间皮瘤患者在多切除术/脱皮术后的生存率有所改善.
科学领域:
- 在瘤学瘤学.
- 胸部外科手术 胸部外科手术
- 恶性多层层层髓瘤 恶性多层层层层瘤
背景情况:
- 排骨间皮瘤是一种具有挑战性的癌症,尽管接受治疗,但其复发率很高.
- 之前的研究已经确定了多切除/脱皮术后复发的结果.
- 这项研究更新了较大,最近的队列中的结果和预后因素.
研究的目的:
- 更新在多切除/脱皮术后多间皮瘤复发的临床结果.
- 确定影响复发后生存的预后因素.
- 评估治疗策略对复发后生存的影响.
主要方法:
- 对251名接受新辅助化疗和多切除/脱皮术 (2012-2022) 的患者进行了回顾性队列研究.
- 卡普兰-梅尔生存率和复发率的方法;用于比较的日志等级测试.
- 多变量Cox比例危险模型用于确定复发后生存的预后因素.
主要成果:
- 75.7%的患者 (190/251) 经历了复发.
- 平均无复发生存时间为21.1个月;平均整体生存时间为44.1个月.
- 对复发后生存的有利预后因素包括:复发后治疗 (HR 0.12),局部复发 (HR 0.45),年龄<70岁 (HR 0.53),和无病间隔>12个月 (HR 0.43).
结论:
- 复发后的治疗,复发模式,复发时的年龄和无病间隔是显著的预后因素.
- 这些因素表明,在接受多切除/脱皮术治疗的患者中,结果有利.
- 识别这些因素有助于预测存活率,并指导复发性多间皮瘤的管理.
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