黄改善了葡萄糖皮质醇诱导的骨质疏松症,同时调节了肠道微生物群和血清代谢
Siying Li1,2, Yating Zhang2, Sujuan Ding2,3
1The Orthopaedic Center, The First People' s Hospital of Wenling, Wenling Hospital of Wenzhou Medical University, Wenling 317500, Zhejiang Province, China.
Journal of agricultural and food chemistry
|March 26, 2025
概括
黄素通过改善肠道细菌和代谢物,减少炎症,有效地对抗葡萄糖皮质激素诱导的骨质疏松症 (GIOP). 这种天然化合物对治疗骨损失和增强骨矿物质密度有前途.
科学领域:
- 生物医学科学 生物医学科学
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
背景情况:
- 葡萄糖皮质醇诱导的骨质疏松症 (GIOP) 是二次骨质疏松症的主要原因.
- 骨肠轴将肠道微生物群和代谢物与骨健康联系起来.
- 库尔库是一种多,正在研究其潜在的抗骨质疏松作用.
研究的目的:
- 为了评估黄素在预防骨损失中的有效性,在GIOP.
- 调查黄素对肠道微生物组合和血清代谢的影响.
- 探索肠道微生物群,代谢物和GIOP中的炎症之间的关系.
主要方法:
- 葡萄糖皮质醇诱导的骨质疏松症的动物模型.
- 用黄素和阿伦德罗酸盐治疗 (阳性对照).
- 评估骨矿物质密度,脊椎骨参数,肠道微生物组测序和血清代谢物分析.
主要成果:
- 黄素治疗显著降低了骨质流失,改善了骨矿物质密度和状骨格参数.
- 黄素和阿伦德罗纳酸都调节了肠道微生物群,增加了有益的细菌 (例如,Akkermansia muciniphila) 并减少了有害的细菌.
- 黄素和阿伦德罗纳酸改变了血清代谢物概况,有益的变化与炎症性细胞因子负相关.
结论:
- 黄素显示出对GIOP有强大的抗骨质疏松作用.
- 黄素调节肠道微生物组和血清代谢组,这表明骨肠轴在其治疗作用中的作用.
- 黄素减少全身炎症的能力突出了其作为GIOP治疗剂的潜力.
相关概念视频
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
92
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
92
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
119
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
119
01:31Osteoclasts in Bone Remodeling
2.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.8K
01:50What is Monogastric Digestion?
70.3K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.3K
01:17Hormones and Bone Tissue
2.5K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.5K
01:29Bone Disorders
3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K