从初级视觉皮质中破坏超视觉电路的破坏影响了两种视觉歧视
C McKinnon1, C Mo2,3, S M Sherman2
1Committee on Computational Neuroscience, University of Chicago, Illinois, USA.
概括
抑制来自主要视觉皮层 (V1) 损伤小鼠的 transthalamic 电路.
科学领域:
- 神经科学是一个神经科学.
- 视觉系统 视觉系统
- 皮层电路 皮层电路
背景情况:
- 从皮质的第5层 (L5) 出生的皮质-甲状腺-皮质 (transthalamic) 电路,在皮质区域之间提供并行通信路线.
- 这些 transthalamic 电路在感知和行为中的确切作用在很大程度上仍未确定.
- 了解这些途径对于破译感官信息如何在层次上被处理以支持感知决策至关重要.
研究的目的:
- 调查L5-启动的 transthalamic 电路在视觉区分表现中的因果作用.
- 为了确定是否选择性抑制主要视觉皮层 (V1) 到脉动通路对视觉感知产生影响.
主要方法:
- 在执行视觉分辨任务的小鼠的脉中针对L5皮质体末端的有针对性的光遗传抑制.
- 选择性抑制来自V1.1的transthalamic电路的产生.
- 对不同视觉刺激方向的行为表现的评估.
主要成果:
- 抑制V1跨体质回路显著损害视觉区分性能.
- 行为缺陷在视网膜上是针对受抑制的V1区域的特异性.
- 这表明了 transthalamic 路径活动和视觉感知之间的因果关系.
结论:
- 由L5启动的跨体质回路对于准确的视觉区分至关重要.
- 这些发现强调了在皮质处理和感知决策模型中包括跨甲状腺途径的重要性.
- 这项研究提供了因果证据,证明视觉 transthalamic 电路在行为中的作用.
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