睡眠与生育能力之间的关联:丹麦预孕队列研究
Mai Hougaard Christensen1, Ellen Margrethe Mikkelsen1, Lauren Anne Wise2
1Department of Clinical Epidemiology and Center for Population Medicine, Aarhus University and Aarhus University Hospital, Aarhus N, Denmark.
European journal of public health
|March 26, 2025
概括
睡眠时间和睡眠困难不会显著影响怀孕概率. 轮班工作显示出生育能力略有增加,而夜班工作显示出潜在的下降,尽管结果尚未确定.
科学领域:
- 生殖健康 生殖健康
- 睡眠医学 睡眠医学
- 职业健康 职业健康 职业健康
背景情况:
- 生育能力,每周期的受孕概率,对于生殖成功至关重要.
- 影响生育能力的因素得到了广泛的研究,人们对生活方式和职业影响日益感兴趣.
- 以前的研究还没有完全阐明睡眠模式和工作时间表对受孕率的影响.
研究的目的:
- 调查睡眠时间,睡眠障碍和职业工作时间 (白天,晚上,轮班,夜晚) 与生育能力之间的关联.
- 量化这些因素对试图怀孕的女性怀孕概率的影响.
主要方法:
- 分析了一项预孕队列研究的数据,该研究涉及10,475名年龄在18-45岁的丹麦女性.
- 基线调查问卷收集了睡眠时间 (小时/天),睡眠困难频率和工作时间的信息.
- 怀孕状态通过随访问卷每8周追踪一次,长达12个月;使用比例概率回归模型.
主要成果:
- 在自我报告的睡眠时间 (≤6,7或≥9小时/天) 或睡眠障碍频率和生育能力之间没有发现显著的关联.
- 与白天工作相比,轮班工作与稍高的生育率有关 (FR=1.12,95% CI:1.04-1.20).
- 夜间工作显示出降低生育能力的趋势 (FR=0.77,95% CI:0.49-1.22),尽管这一发现不准确.
结论:
- 睡眠时间和主观睡眠障碍似乎不会显著影响女性怀孕的可能性.
- 轮班工作可能与生育能力的适度增加有关,而夜间工作可能与生育能力的下降有关,需要进一步调查.
- 限制包括睡眠的潜在错误分类和未测量的混因素.
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