血清低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比率预测下泌尿道功能障碍相关的脂质失调症
Yuki Harigane1, Hidenori Akaihata1, Kei Yaginuma1
1Department of Urology, Fukushima Medical University School of Medicine.
失脂症,指的是高的LDL-C/HDL-C比率,与减少膀收缩率和更大的排泄体积有关,在没有膀出口阻塞的男性中. 2.15或更高的比率可能表明这种功能障碍.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 心血管健康 心血管健康
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 下尿道功能障碍 (LUTD) 影响了许多男性.
- 脱脂症是一种常见的代谢障碍.
- 脱脂症对膀功能的影响,独立于膀出口阻塞 (BOO),需要进一步研究.
研究的目的:
- 探索通过LDL-C/HDL-C比率量化的脂质不良症与下泌尿道功能之间的关系.
- 评估不同LDL-C/HDL-C比率的患者的膀收缩性,不包括BOO患者.
主要方法:
- 在机器人辅助激进前列腺切除术之前,对患者进行了尿动力学研究.
- 没有包括患有糖尿病或BOO (Schäfer nomogram阻塞III-V) 的患者.
- 分析了手术前的LDL-C/HDL-C比率与尿动力学参数,特别是膀收缩强度之间的关联.
主要成果:
- 共有52名患者被纳入该研究.
- 较高的LDL-C/HDL-C比率与空化体积的增加显著相关 (P=0.041).
- 膀收缩较弱的患者与收缩较强的患者相比,LDL-C/HDL-C比率显著更高 (P=0.047).
结论:
- 失脂症可能导致LUTD,其特点是膀收缩率降低和更大的空气体积.
- 2.15或更高的LDL-C/HDL-C比率可以作为在没有BOO的男性中因失脂症引起的LUTD的预测标记.
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