在有物质使用障碍的个体中滥用 gabapentinoids
İnci Sağlam1, Rukiye Aslan2, Serap Annette Akgür2
1Manisa Mental Health and Disorders Hospital, Manisa, Turkey.
Journal of forensic sciences
|March 26, 2025
概括
尽管有监管规定,土耳其对 gabapentinoid 的滥用,包括pregabalin 和 gabapentin,正在迅速增加. 增加的阳性率和与甲基胺等物质的共同使用凸显了迫切的公共卫生问题.
科学领域:
- 法医毒理学 法医毒理学
- 成 药物 药物 药物 药物
- 药物监督 药物监督 药物监督
背景情况:
- 对 gabapentinoids 的滥用越来越严重,导致相关死亡人数的增加.
- 在土耳其实施了法律法规,以解决 gabapentinoid 滥用问题,需要对其影响进行审查.
研究的目的:
- 分析土耳其药物滥用案件中的毒理学数据.
- 在这些案例中调查 gabapentinoid 阳性的医疗法律影响.
- 评估 gabapentinoid 使用和与其他物质共同使用的流行率和模式.
主要方法:
- 使用高分辨率液态染色体质谱法 (Orbitrap) 来对10,300名 (18-45岁) 患有物质使用障碍的个体的尿样进行毒理学分析.
- 从患者记录中检索和统计分析社会人口统计数据和分析报告.
- 专注于检测普雷加巴林 (PGB), gabapentin (GBP) 和同时出现的物质.
主要成果:
- 在21.6%的病例中检测到 gabapentinoid 的阳性 (PGB: 18.9%, GBP: 5.3%).
- 大多数阳性病例是男性 (93.9%),平均年龄为28岁.
- 甲基胺 (46.8%) 和THC-COOH (26.8%) 是最常见的同时出现的物质.
- 随着时间的推移,PGB和GBP正面率的统计显著增加被观察到 (p < 0.05).
结论:
- 尽管有法律规定,但在土耳其, gabapentinoid 的使用正在迅速增加.
- 与其他非法物质,特别是甲基胺的高共同阳性率构成重大公共卫生风险.
- 迫切需要将 gabapentinoids 纳入常规查,更严格的处方准则,并加强非法使用的预防.
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