在乳腺癌基因表达数据中的特征选择使用KAO和AOA与SVM分类
Abrar Yaqoob1, Navneet Kumar Verma2
1School of Advanced Sciences and Languages, VIT Bhopal University, Sehore Bhopal, 466114, India. abraryaqoob77@gmail.com.
Journal of medical systems
|March 27, 2025
概括
这项研究提出了一种新的混合优化框架,用于使用基因表达数据对乳腺癌进行分类. 该方法通过选择最相关的基因来实现高精度,有助于早期癌症预测.
科学领域:
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
- 医疗保健中的机器学习
背景情况:
- 根据基因表达数据对乳腺癌进行分类是具有挑战性的,因为它具有很高的维度.
- 现有的方法在特征冗余和过早的融合方面扎.
研究的目的:
- 开发一种新的混合优化框架,用于有效的基因选择和乳腺癌分类.
- 使用基因表达特征提高癌症预测的准确性和效率.
主要方法:
- 一个混合框架,将克什米尔果优化算法 (KAO) 和阿马迪罗优化算法 (AOA) 结合起来进行特征选择.
- 用于精确分类乳腺癌亚型的支持矢量机器 (SVM).
- 全球基因探索和本地改进的双阶段优化方法.
主要成果:
- 获得了98.97%的分类准确度,98.46%的精度,100%的回忆率和99.22%的F1分数.
- 确定了15个基因的高度信息化的子集,用于准确的乳腺癌分类.
- 在不同的基因子集大小中表现出强大且一致的高性能.
结论:
- 该KAO-AOA混合框架为基因基因癌症预测提供了一个强大的工具.
- 优化的特征选择减少了冗余性,提高了分类准确性.
- 该框架显示了对各种癌症数据集和临床环境的应用潜力.
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