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Updated: May 20, 2025

Titration ELISA as a Method to Determine the Dissociation Constant of Receptor Ligand Interaction
12:38

Titration ELISA as a Method to Determine the Dissociation Constant of Receptor Ligand Interaction

Published on: February 15, 2018

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药物定位悖论在存在个体内变化的情况下:我们可以估计真正的度-效果关系吗?

Sebastiaan C Goulooze1,2, Elke H J Krekels3,4, Catherijne A J Knibbe4,5

  • 1LAP&P Consultants BV, Archimedesweg 31, 2333 CM, Leiden, The Netherlands. b.goulooze@lapp.nl.

The AAPS journal
|March 27, 2025
PubMed
概括

药物定位悖论可能会影响暴露-反应 (ER) 建模. 像静态微分方程 (SDE) 或残余误差自相对应等先进的方法成功估计了真实的ER关系,避免了因个体内变化而产生的偏差.

关键词:
自动相关性 自动相关性这是一个偏见的偏见.药物定位 药物定位 药物定位暴露与反应分析.在个体内部的变化.

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