通过数字和传统方法生产的临时固定假肢材料的单体释放,细胞毒性和表面粗性
Zeynep Sahin1, Deniz Ozkan Vardar2, Ekin Erdogmus3
1Department of Prosthodontics, Faculty of Dentistry, Lokman Hekim University, Ankara, Turkey. dtsahinzeynep81@gmail.com.
Odontology
|March 27, 2025
概括
这项研究发现,CAD/CAM削和双烯复合树脂 (PT) 材料对临时假体具有生物相容性,与显示细胞毒性的3D打印材料不同. 从任何测试的临时假肢材料中没有检测到单体释放.
科学领域:
- 牙科材料科学 牙科材料科学
- 生物材料工程 生物材料工程
- 牙修复 牙修复 牙修复 牙修复 牙修复
背景情况:
- 临时固定的假肢材料对于在牙科治疗期间保持功能和美学是至关重要的.
- 评估不同制造方法的生物相容性和材料特性对于临床安全至关重要.
- 传统的CAD/CAM削和3D打印技术为制造临时修复提供了不同的方法.
研究的目的:
- 为了比较通过传统,CAD/CAM削和3D打印方法生产的临时假肢材料的表面粗度,单体释放和细胞毒性.
- 评估聚乙烯甲基酸/聚甲基酸 (DP),双烯复合树脂 (PT),聚甲基酸CAD/CAM光盘和基于甲基酸的树脂 (QuraCROWN Temp) 的生物相容性.
- 根据体外试验,确定这些材料是否适用于临时固定假肢修复.
主要方法:
- 使用传统的CAD/CAM削和3D打印技术制造了圆盘形样本.
- 测量了表面粗度,并使用扫描电子显微镜 (SEM) 进行了表面表征.
- 细胞毒性使用MTT测定在人工唾液中化后对小鼠纤维细胞进行了评估,单体释放被高性能液体染色学 (HPLC) 和ATR-FTIR分析.
主要成果:
- 对于任何测试材料,在人工唾液中没有检测到单体或聚合物释放.
- 与传统的,CAD/CAM加工的和PT材料相比,3D打印材料的细胞毒性明显更高.
- 数字制造的材料 (CAD/CAM削) 的表面粗度低于传统生产的材料. 在CAD/CAM削和PT材料中,细胞活力最高,表明生物相容性良好.
结论:
- CAD/CAM削和双烯复合树脂 (PT) 材料是生物相容的,适合临时的假肢修复.
- 3D打印的临时假肢材料显示出细胞毒性,在临床应用之前需要进一步调查.
- 没有观察到有关单体或聚合物释放,但细胞毒性仍然是制造方法之间的关键差异化因素.
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