益生菌在结直肠癌预防和治疗中的作用:机制,益处和挑战
Djilali Seghir Morsli1, Hadja Fatima Tbahriti2,3, Fouzia Rahli1,4
1Higher School of Biological Sciences of Oran, Oran, Algeria.
Discover oncology
|March 27, 2025
概括
益生菌因其抗炎作用而显示出结直肠癌 (CRC) 治疗的潜力. 需要进一步的研究来证实它们作为超越食补充剂的治疗效果.
科学领域:
- 胃肠道学和瘤学
- 微生物学和免疫学
背景情况:
- 结肠直肠癌 (CRC) 是全球和阿尔及利亚癌症发病率和死亡率的主要原因.
- 糟糕的生活方式因素显著增加了CRC风险.
- 益生菌具有抗炎和抗瘤的特性,被世界卫生组织和EFSA认可的安全性.
研究的目的:
- 审查关于用于结直肠癌治疗的益生菌菌株的当前知识.
- 检查CRC中益生菌的治疗潜力,局限性和未来研究方向.
主要方法:
- 关于益生菌和CRC的临床前和临床研究的文献综述.
- 对益生菌安全分类 (GRAS,QPS) 的分析.
- 检查免疫调节效应和肠道微生物群的影响.
主要成果:
- 益生菌显示出抗炎和抗瘤作用.
- 它们调节免疫系统,保持肠道微生物群平衡.
- 目前对疗效的临床证据不足以进行治疗分类.
结论:
- 益生菌看起来很有前途,但需要更多的研究才能被确立为CRC治疗方法.
- 由于潜在的感染风险,高风险患者应谨慎使用.
- 进一步的研究是必要的,以提高益生菌在CRC管理中的有效性.
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