患有食道状细胞癌上三分之一的患者在新辅助免疫化学疗法后具有更好的瘤回归
1Department of Thoracic Surgery, Army Medical Center of PLA (Daping Hospital), Army Medical University, Chongqing, PR China.
Annals of surgical oncology
|March 27, 2025
概括
新辅助性免疫化学疗法 (NICT) 对食道上方状细胞癌 (ESCC) 显示出更大的临床益处. 在食道上部的瘤位置可以预测在局部发达的食道癌症中对NICT的更好的反应.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 胃肠病学 胃肠病学
背景情况:
- 新辅助免疫化学疗法 (NICT) 在局部晚期食道癌 (AEC) 中显示出有效性.
- 之前的试验支持NICT超过新辅助化疗 (NCT) 或化疗放射治疗.
- 这项研究调查了NICT在不同食道段的疗效.
研究的目的:
- 评估NICT在各种食道状细胞癌 (ESCC) 分段中的疗效.
- 确定NICT响应的预后因素.
- 确定瘤位置是否能预测治疗结果.
主要方法:
- 对248名患有AEC的患者进行了回顾性队列研究.
- 在进行激进手术之前,患者接受了2-4个NICT周期.
- 分析了ESCC瘤位置与临床/病理特征之间的关系.
主要成果:
- 上胸部ESCC瘤显示出较高比例的较低瘤回归度 (TRG 0-1).
- 下胸部瘤位置与更高的TRG (2-3) (OR,3.298;P = 0.003) 有关.
- 更高的TRG也与临床T3 (OR, 2.834) 和N2阶段 (OR, 2.557) 有关.
结论:
- 上三分之一的ESCC患者可能比下三分之一的ESCC患者更受益于NICT.
- 瘤位于食道上部的位置可能是NICT疗效的预测因素.
- 需要进一步的研究来证实这些发现.
更多相关视频
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
11.4K
04:04Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
10.4K
相关概念视频
01:27Tumor Immunotherapy
450
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
450
02:17The Tumor Microenvironment
6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K